Clinical Trials
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APPLE study- Atherosclerosis Prevention in Pediatric Lupus Erythematosus
This is an NIH sponsored placebo controlled double blinded study evaluating the safety and efficacy of atorvastatin, a lipid lowering agent, in patients with pediatric SLE. Stanford Pediatric rheumatology is one of the multiple sites across the country participating in this 1st ever clinical research trial in pediatric systemic lupus erythematosus. This trial also is the flagship clinical study for the Childhood Arthritis & Rheumatology Research Alliance (CARRA) [http://carragroup.org/].
Primary Investigator: Christy Sandborg
Closed to Enrollment
- TREAT study- TRial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis
This is a NIH sponsored multicenter study evaluating early aggressive treatment of Polyarticular Juvenile Idiopathic Arthritis.
Primary Investigators: Christy Sandborg, Joyce Hsu, Tzielan Lee, and Jennifer Frankovich
Contact: Joyce Hsu
- A Multi-center, Randomized, Double Blind, Placebo-controlled Study to Test the Safety and Efficacy Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (RAPPORT)
This is a NIH sponsored multicenter study evaluating the use of anti IL-1 biologic medications in patients with severe juvenile arthritis.
Primary Investigators: Christy Sandborg, Joyce Hsu, Tzielan Lee, and Jennifer Frankovich
Contact: Tzielan Lee
- RAPPORT Study - Randomized Placebo Phase Study of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis (JIA)
This is an NIH sponsored study to test the efficacy of an IL-1 inhibitor (rilonacept) on the articular and extra-articular (systemic) manifestations of SJIA. The trial will utilize a randomized placebo phase design based on a randomized placebo phase of 4 weeks and time to response up to 12 weeks. The primary endpoint will be time to response defined as the adapted ACR Pediatric 30 (AAP 30) coupled with a required corticosteroid taper based on predetermined conditions. One hundred children under the age of 20 years old, with SJIA, from 20 CARRA centers will be enrolled. Data collected over 24 weeks will be used to assess durability of response and safety.
Primary Investigators: Christy Sandborg
Contact: Anne C Marcy
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